There are no meta predicates in SPASS available. Hence, this functionality is not directly supported. However it can be achieved by a trick. The idea is to add a new literal to the conjecture clause that carries the substitution and will definitely be resolved away in the final step of the proof. For example: let x be the variable where we are interested in the subsitution. Let x occur in the single conjecture clause C. Then extend this clause to C,P(x,a,y) and add the clause -P(z,u,b), where P is new, and a,b are constants. Furthermore make P a minimal predicate using a set_DomPred declaration (see the SPASS man page). This will force that the final step in the proof is the one that eliminates the P literal and the x will be instantiated accordingly. To make this work it may be necessary to turn off certain reduction rules of SPASS. To get it rid of that, a trick is to extend all predicates in C by a further argument with the variable y and all other occurrences of these predicate with fresh variables.